Psychological stress is associated with a greater risk for depression, heart disease and infectious diseases.
A 2012 research team led by Carnegie Mellon University’s, Sheldon Cohen has found that chronic psychological stress is associated with the body losing its ability to regulate the inflammatory response. There is nothing new in these findings, as every naturopath, every day see results of prolonged and chronic stress on patients’ health manifested in many ways. Published research shows for the first time that the effects of psychological stress on the body’s ability to regulate inflammation can promote the development and progression of the disease.
“Inflammation is partly regulated by the hormone cortisol and when cortisol is not allowed to serve this function, inflammation can get out of control,” said Cohen.
Cohen argued that prolonged stress alters the effectiveness of cortisol to regulate the inflammatory response because it decreases tissue sensitivity to the hormone. Specifically, immune cells become insensitive to cortisol’s regulatory effect. In turn, runaway inflammation is thought to promote the development and progression of many diseases.
Cohen, whose groundbreaking early work showed that people suffering from psychological stress are more susceptible to developing common colds, used the common cold as the model for testing his theory. With the common cold, symptoms are not caused by the virus — they are instead a “side effect” of the inflammatory response that is triggered as part of the body’s effort to fight infection. The greater the body’s inflammatory response to the virus, the greater is the likelihood of experiencing the symptoms of a cold.
In Cohen’s first study, after completing an intensive stress interview, 276 healthy adults were exposed to a virus that causes the common cold and monitored in quarantine for five days for signs of infection and illness. Here, Cohen found that experiencing a prolonged stressful event was associated with the inability of immune cells to respond to hormonal signals that normally regulate inflammation. In turn, those with the inability to regulate the inflammatory response were more likely to develop colds when exposed to the virus.
In the second study, 79 healthy participants were assessed for their ability to regulate the inflammatory response and then exposed to a cold virus and monitored for the production of pro-inflammatory cytokines, the chemical messengers that trigger inflammation. He found that those who were less able to regulate the inflammatory response as assessed before being exposed to the virus produced more of these inflammation-inducing chemical messengers when they were infected.
“The immune system’s ability to regulate inflammation predicts who will develop a cold, but more importantly it provides an explanation of how stress can promote disease,” Cohen said. “When under stress, cells of the immune system are unable to respond to hormonal control, and consequently, produce levels of inflammation that promote disease. Because inflammation plays a role in many diseases such as cardiovascular, asthma and autoimmune disorders, this model suggests why stress impacts them as well.”
He added, “Knowing this is important for identifying which diseases may be influenced by stress and for preventing disease in chronically stressed people.”
Sheldon Cohen, Denise Janicki-Deverts, William J. Doyle, Gregory E. Miller, Ellen Frank, Bruce S. Rabin, and Ronald B. Turner. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. PNAS, April 2, 2012 DOI: 10.1073/pnas.1118355109
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Danuta Hulajko is a holistic practitioner, international speaker, the founder and the practitioner at the DH Natural Medicinhealingremedies.com.aue Clinic and www.healingremedies.com.au, Southern Highlands. She specialises in anti-aging, autoimmunity, thyroid conditions, digestive disorders and heavy metals chelation. For more information please go to our website. You can follow Danuta Hulajko work, events, seminars, expos, latest health research, her health tips and advice on Facebook and LinkedIn